A B Simpson

Culturing Excellence

Prio to 2010, Pfizer Health AB produced its legacy products Genotropin® and Somavert® in separate facilities. Somavert was sourced from a contract manufacturer while Gentropin was manufactured at a Pfizer facility in Strängnäs, Sweden.

The two drugs have opposite effects on the human physiology - Genotropin is used to treat growth hormone deficiency and Somavert is a growth hormone antagonist - but the proteins used in each are very similar. Pfizer’s development scientists saw an opportunity to exploit this similarity to develop almost identical unit operations that could be used for both products within the same facility.

The project - dubbed Project Pegasus - had two fundamental ground rules: The new Bio 7 facility would not require an increased head count and a two-shift pattern would be sufficient to produce two batches per week. To achieve this, the project team went back to the drawing board and re-evaluated a number of steps in the manufacturing process, including some thought to be standard in pharmaceutical processing.

Today, the Bio 7 facility is able to produce the two

Time is Money

The FOYA judging panel recognized the effort that Pfizer put

Four CIP skids are used to provide dedicated cleaning

CIP time is further reduced by eliminating the purified

Further tests found that the manual removal and

SIP Realities

Conventional wisdom suggests that SIP functionality should

The Project Pegasus team found that the added value from

Pharmaceutical Counterculture

The ability to improve efficiency by questioning and

“Every voice and idea counts no matter where it comes from.

“We also communicated that not everything could be

Risk-based approaches helped Sandell’s team challenge

“We used risk-assessment technologies such as failure mode

And what is Sandell most proud of?

“We built Bio 7 in a platform technology - I like to compare

Jun 17 | Girish Malhotra, PE, President, EPCOT International

In my recent trip to India, during my discussion with Shire - Facility of the Year Award Winner - Honorable Mention

Apr 11 | Video

Dave Forney from Shire talks to Pharmaceutical Processing's Editor In Chief Mike Auerbach during INTERPHEX 2011 about the company's Human Genetics Therapies (HGT) Project Atlas facility in Lexington, Massachusetts. The facility has won the Honorable Mention award in the 2011 Facility of the Year Award competition sponsored by ISPE, INTERPHEX and Pharmaceutical Processing magazine.

Trivium Pursuit » Blog Archive » Bearing the Sting by A. B. Simpson

Bearing the Sting

“He opened not his mouth” (Isa. 53:7).

How much grace it requires to bear a misunderstanding rightly, and to receive an unkind judgment in holy sweetness! Nothing tests the Christian character more than to have some evil thing said about him. This is the file that soon proves whether we are electro-plate or solid gold. If we could only know the blessings that lie hidden in our trials we would say like David, when Shimei cursed him, “Let him curse;… it may be that the Lord will requite me good for his cursing this day.”

Some people get easily turned aside from the grandeur of their life-work by pursuing their own grievances and enemies, until their life gets turned into one little petty whirl of warfare. It is like a nest of hornets. You may disperse the hornets, but you will probably get terribly stung, and get nothing for your pains, for even their honey is not worth a search.

God give us more of His Spirit, “who, when he was reviled, reviled not again”; but “committed himself to him that judgeth righteously.” “Consider him that endureth such contradiction of sinners against himself.”

–A. B.

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